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Die Ursachen von Impotenz können vielschichtig sein. Bei Männern ab 50 Jahren, sind es meistens andere Erkrankungen, wie Arteriosklerose oder Bluthochdruck, die für eine Impotenz verantwortlich sein können. Dann ist die Impotenz ein wichtiges Frühwarnzeichen für diese Erkrankungen. Besonders in der Altersgruppe bis 35 Jahre ist bei etwa 20 Prozent der Fälle die Impotenz psychisch bedingt. Die Erektion des Penis beruht auf einem verstärkten Blutfluss in den Schwellkörper. Dazu müssen sich die Arterien erweitern. Dies ist nur möglich, wenn die umliegende Muskulatur erschlafft.

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Sildenafil ist ein PDE-5-Hemmer. Es blockiert das Enzym Phosphodiesterase 5. Dadurch bleibt mehr cGMP im Blutkreislauf, die Muskelentspannung erhöht sich und die Erektion wird verbessert.
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